Wednesday, June 19, 2013

Robert Krulwich - Why Men Die Younger Than Women: The 'Guys Are Fragile' Thesis

Over at his NPR blog, Krulwich Wonders, Robert Krulwich looks at the evidence for the "guys are fragile" thesis to explain why men die, on average, quite a bit younger than women.

Some of the evidence:

  • "the ratio of males to females ... has been estimated to be from 107 to 170 males per 100 females."
  • "105 males are born for every 100 females"
  • "male disadvantage spikes during the teens and early twenties, when young men fight, go to war, dare, and don't wear motorcycle helmets - deaths are increasingly accidental, suicidal, homicidal or war related"
  • "In America, nine out of 10 of the so-called "supercentarians" (over 110) are female"

It doesn't look good for the males. Some of the things that make us male, make us masculine, may also lead us to younger deaths.

Why Men Die Younger Than Women: The 'Guys Are Fragile' Thesis


by ROBERT KRULWICH
June 17, 2013

The 19th century just lost its last living man.

Jiroemon Kimura, of Kyotango, Japan, was born in April 1897, lived right through the 20th century and died last Wednesday. He was 116. According to the Guinness Book of Records (which searches for these things) he was the last surviving male born in the 1800s. All the other boys from that century, as best we know, are dead.

The ladies, however, are still ticking. Misao Okawa of Osaka is now officially the oldest person on the planet. She was born in 1898. There are four others, two in Britain, one in the USA, and another in Japan — all 19th century-born, all female, all still alive.

Once again, the ladies have outlasted the gentlemen. Not that that's a big surprise.

They Might Be Giants - Older

Women, on average, seem to take a little longer to die. But here's what I didn't know. Women, it turns out, don't just win in the end. It seems that women consistently outlive men in every age cohort. Fetal boys die more often than fetal girls. Baby boys die more often than baby girls. Little boys die more often than little girls. Teenage boys, twenty-something boys, thirty-something boys — in every age group, the rate of death for guys is higher than for women. The difference widens when we hit our fifties and sixties. Men gallop ahead, then the dying differential narrows, but death keeps favoring males right to the end.

After that, everybody's dead.

So Death, it turns out, is not an equal opportunity avenger. It seems to consistently favor males. Why? What is it about maleness that brings Death knocking?

The Fetal Difference


First off, whatever we males are doing wrong, nature seems to know about it. Because when human babies are conceived, says a 2002 study, "the ratio of males to females ... has been estimated to be from 107 to 170 males per 100 females." The storks, it seems, drop extra boy babies into wombs, almost as if they know what's coming. But even with a boost at conception, male fetuses don't make it out of the uterus as often as female fetuses. The death differential, says the study, "has been estimated to be from 111 to 160 males per hundred females." So miscarriages are mostly male.

The Baby Difference


Then come birthdays. More boy babies get born than girl babies. This is true all over the world. In America, it's 105 males for every 100 females. But as soon as they're out, the boys start to go. Male babies born prematurely die more often than females. Birth weight is not as strong a predictor as gender. You can be born impossibly small, and if you're a girl you are still slightly more likely to make it through.

The Adolescent Difference


The male disadvantage spikes during the teens and early twenties. This is the time when young men fight, go to war, dare and don't wear motorcycle helmets. Their deaths here are increasingly accidental, suicidal, homicidal or war related. "If deaths from violence are excluded," says a study from the Society of Actuaries, the spike in the early 20s disappears completely, though the female advantage remains. Not too long ago, young women got pregnant and many died having babies during their twenties, but in the modern era, childbirth mortality is down; male derring-do less so.

The Middle Years Difference


Here the gender difference narrows and holds steady, but if you look across the years, men are more likely to die from injuries, and (at least in the USA), from suicide, respiratory cancer, cirrhosis of the liver, emphysema and coronary heart disease. The leading female diseases, breast cancer and cervical cancer, do damage, but not as much as the male diseases.

The Oldies Difference


Somewhere in our fifties, the men begin to accelerate their dying, and that difference peaks in our sixties and early seventies and then narrows. In the last lap, among the oldest of the oldies — people 110 and over — women are lopsidedly the survivors. In America, nine out of 10 of the so-called "supercentarians" are female. Jiroemon Kimura, the farmer/mailman who died last week in Japan, — was a double exception; he was not only super-old, he was a super-old male. That's very rare.

They Might Be Giants - Older

But Why The Difference?


Which brings us back to the deeper question (again, we're talking not about you in particular; we are making a statistical argument based on averages): Is there something about being a male that all by itself, shortens a lifespan? And if so, is it correctible or built-in? The most famous paper on this subject Why Men Die Younger, comes from an actuary (naturally) working in Seattle, Barbara Blatt Kalben. In 2002, she wrote that being a guy is definitely more dangerous, but she has a bevy of reasons why that might be, and she doesn't choose a winner.

Blame Testosterone?


There are obvious behavioral differences between men and women, she writes. Some of them might be cultural. Men are more violent which puts them in harm's way more often. They consistently consume more tobacco, alcohol and drugs, which makes them sicker (then deader) later on. The explanations for this difference could be chromosomal or hormonal (more testosterone) and therefore hard to change; or they could be learned.

Blame Size?


Other explanations seem hard-wired, and not fixable. Men, she notes, are generally bigger, which reflects a general rule in biology, seen in most species, which says (quoting from a study) "that larger (size) individuals (within a species) tend on average to have shorter lives." This has proven true for animals in the wild, showing up in worms, fish, insects, mammals, and, of course, our group, the primates. The bigger among us (again, on average) die earlier. (I've noticed this among dogs, but birds, she says, are a notable exception — Big Bird, if he existed, would likely to last longer than your average garden robin.)

But now comes the explanation that made me wince.

Blame Male Weakness


Barbara Kalben mentions it, quoting an author named "Allen" (I couldn't find his full name, not having access to her bibliography) but he apparently studied data from the Mayo Clinic and in 1934 wrote an essay that said that "mere maleness" is predictor of greater mortality. Something about being male "influences unfavorably the resistance ... to disease at all ages." He called it "male weakness."
The factors which are usually set down in explanation of the greater mortality in males are overwork, alcoholism, venery [I looked it up, it means lots of sex and also hunting] tobaccoism, exposure to the elements, industrial hazards, and irregular habits of eating and sleeping. ... 
For each explanation of the lack of inherent vitality of the male there are objections, but these do not influence the fact; the male is, by comparison with the female, a weakling at all periods of life from conception to death. Venery, alcoholism, exposure, overwork, and various other factors may influence the susceptibility to disease and the greater mortality of the adult male, but they are only straws placed on the greater burden of his sex-linked weakness. 
There seems to be no doubt that, speaking comparatively, the price of maleness is weakness.
So, for many reasons, because of our hormones, our chromosomes, our lifestyle, the stresses of being a guy, we become (or are born) more fragile. This is not exactly my image of maleness, which runs more to Achilles or to Muhammad Ali, but the data suggests in the long run, when it comes to just surviving, it's the ladies who pack steel.

A bunch of years ago on ABC News, in a series I did with Ted Koppel called Brave New World, I touched on the theme of time with two friends of mine, John Lennell and John Flansburgh, better known as They Might Be Giants. They made a music video to illustrate our hour-long essay, which included this refrain: "You're Older Than You Were Before, And Now You're Even Older..." lines that make me smile to this day. Both the Johns and the three musicians they hired (all named Dan) and I (I introduce the song) are older than we were before ... and, as sometimes happens, now we're even older. Notice, there are no women in the video. If we'd included any, chances are they'd have gone on and on and on and, in a gender-embarrassing way, outlasted us.

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